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Turn Biotechnologies Working For A Nobel Prize

Stanford researchers claim that "Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development".

The finding may have HUGE implications for aging research and "(...) may one day have the opportunity to reboot entire tissues (...) but first we want to make sure that this is rigorously tested in the lab and found to be safe. (...)” [Source] said Vittorio Sebastiano, PhD, assistant professor of obstetrics and gynecology and the Woods Family Faculty Scholar in Pediatric Translational Medicine (also: CoFounder & Scientific Advisory Board Chairman at Turn Biotechnologies).

The researchers found that elderly mice regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating protein treatment and transplanted back into their bodies. (Read: iPSC Tech Rejuvenates Aging Muscle Cells to Give Mice Youthful Strength).

 “We saw a dramatic rejuvenation across all hallmarks but one in all the cell types tested,” Sebastiano said. “But our last and most important experiment was done on muscle stem cells. Although they are naturally endowed with the ability to self-renew, this capacity wanes with age. We wondered, Can we also rejuvenate stem cells and have a long-term effect?”

When the researchers transplanted old mouse muscle stem cells that had been treated back into elderly mice, the animals regained the muscle strength of younger mice, they found.

Finally, the researchers isolated cells from the cartilage of people with and without osteoarthritis. They found that the temporary exposure of the osteoarthritic cells to the reprogramming factors reduced the secretion of inflammatory molecules and improved the cells’ ability to divide and function.

The researchers are now optimizing the panel of reprogramming proteins needed to rejuvenate human cells and are exploring the possibility of treating cells or tissues without removing them from the body.

Adapted from both the press brief found here: of 03/24/20 by Krista Conger is a science writer in the Office of Communications and the press announcement from Turn Biotechnologies {} found here: Research Shows Promise of Technology Used by Turn Biotechnologies to Develop Therapies for Age-Related Diseases


March 2020

Turning Back the Clock on Aging Cells - New York Times: “A major cause of aging is thought to be the errors that accumulate in the epigenome, the system of proteins that packages the DNA and controls access to its genes. The Stanford team, led by Tapash Jay Sarkar, Dr. Thomas A. Rando and Vittorio Sebastiano, say their method, designed to reverse these errors and walk back the cells to their youthful state, does indeed restore the cells’ vigor and eliminate signs of aging.” See the NYT article.

Radio host: “Last question, how soon do you think you might be able to do it in humans and as part of that, can I be one of your test studies?” Listen to the interview on the BBC!

We read on “Notably, if the expression of the reprogramming factors is only transiently applied and then stopped (before the so-called Point of No Return, PNR), the cells return to the initiating somatic cell state. These observations suggest that, if applied for a short enough time, the expression of reprogramming factors fails to erase the epigenetic signature defining cell identity.” ... Full article.

An Interview with Prof. Vittorio Sebastiano of Turn.Bio



"Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several ‘rejuvenating’ interventions have been proposed to delay ageing and the onset of age-associated decline and disease to extend healthspan and lifespan. These interventions include metabolic manipulation, partial reprogramming, heterochronic parabiosis, pharmaceutical administration and senescent cell ablation. As the ageing process is associated with altered epigenetic mechanisms of gene regulation, such as DNA methylation, histone modification and chromatin remodelling, and non-coding RNAs, the manipulation of these mechanisms is central to the effectiveness of age-delaying interventions. This Review discusses the epigenetic changes that occur during ageing and the rapidly increasing knowledge of how these epigenetic mechanisms have an effect on healthspan and lifespan extension, and outlines questions to guide future research on interventions to rejuvenate the epigenome and delay ageing processes." More/Source:

Further reading related to ageing research in general: